The role of sirtuin 1 on the induction of trained immunity

Sirtuin 1 (SIRT1) has been described to modify immune responses by modulation of gene transcription. As transcriptional reprogramming is the molecular substrate trained immunity, a de facto innate memory, we investigated role SIRT1 in induction immunity. We identified various genetic single nucleotide polymorphisms affecting and adaptive cytokine production human peripheral blood mononuclear cells (PBMCs) response stimuli on one hand, vitro immunity other hand. Furthermore, inhibition upregulated pro-inflammatory upon stimulation PBMCs. However, had no effect while activation mildly modified responses. In conclusion, modifies PBMCs microbes, but only secondary for BCG ?-glucan-induced